It is our aspiration to comprehend and investigate the relationships between pharmaceutics and technology more deeply. For this purpose, we cooperate with universities, conduct our own and contract research, and we supervise bachelor, master and doctoral theses.
By means of instrumentation and measurement technology we observe single aspects within the manufacturing process of solid dosage forms. The choice of aspects depends on the actual question, and the findings usually allow us to improve regulating and monitoring of the process. This ultimately leads to an increase of product quality.
Optimization & Innovation
We closely cooperate with mechanical engineers within the pharmaceutical field. Here, we concentrate on optimizing individual machines, facilities for continuous manufacturing, and research into innovative measurement methods.
Depending on the question, machines can be equipped with additional force transducers and displacement measurement systems. Acquisition and evaluation of measurement data and its implementation to machine control can play a decisive role in this.
In addition, we developed an external data acquisition software for tableting presses that enables us to verify the internal machine software‘s measuring procedures and measurement data and to improve it accordingly. This external software can be used universally for all tableting presses.
Due to their innovative nature, many cooperative research projects are subject to non-disclosure. Naturally, we respect this, and we cover these projects only with the client‘s explicit consent.
Have you come up with an idea? Do you need support for its execution or evidence of relevance? Or are you simply looking for a partner to discuss your ideas?
Give us a call or schedule a meeting.
On behalf of Romaco Kilian, we developed a measurement method to examine a powder with ultrasound while it is beeing pressed to a tablet. This way, parameters relevant to tableting become gaugeable. This method is called Kilian Inline Measurement (KIM). Once the patent for ultrasonic measurement was granted to Romaco Kilian, we cooperated to develop the details for adapting the application to tableting presses. At first, we equipped a Styl‘One Evo with the new instruments and initially had to break down some instrumentational barriers. The system measures the speed of ultrasonic longitudinal and transversal waves within the powder during compression. In combination with the exact powder bed height, Young‘s modulus and the Poisson‘s ratio can be calculated. Comprehensive tests and evaluations showed that several pharmaceutically relevant parameters such as compatibility of powders can be deduced.
Do you want to learn more about KIM? Please give us a call or send us an email. The system is set-up in our lab, and you can assign us your trials or visit us for a demonstration.
In cooperation with the university of Bonn and the company ColVisTec, we are currently developing an in-line measurement method to determine ribbon density on roller compactors. The ribbons are to be scanned using ColVisTec glass fibers and the density is to be deduced from the resulting color spectrum.
Initial trials to verify the measurement method were performed offline with tablets and ribbons. Since the results look promising, we have now entered the constructing phase of the mounting for the measuring device. Once the device can be mounted, an extensive experimental program will be performed. The project is funded by ZIM, the central innovation program for small and medium-sized enterprises.
ZIM – Germany’s largest innovation program for small and medium-sized enterprises – Funding program of the Federal Ministry for Economic Affairs an Energy